Human ID2 protein (Recombinant) (His-Tag) (STJP018098)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ID2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ID2 |
| Gene ID | 3398 |
| Uniprot ID | ID2_HUMAN |
| Accession Number | NP_002157 |
| Immunogen | Human |
| Immunogen Region | 1-134aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MKAFSPVRSV RKNSLSDHSL GISRSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS KMEILQHVID YILDLQIALD SHPTIVSLHH QRPGQNQASR TPLTTLNTDI SILSLQASEF PSELMSNDSK ALCG |
Additional Info
| Tissue Specificity | Highly expressed in early fetal tissues, including those of the central nervous system. |
| Post Translational Modifications | Ubiquitinated in a ASB4-depedent manner, leading to proteasomal degradation. Phosphorylated in vitro by CDK1, PKA and PKC. |
| Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. |
| Protein Name | Dna-Binding Protein Inhibitor Id-2Class B Basic Helix-Loop-Helix Protein 26Bhlhb26Inhibitor Of Dna Binding 2Inhibitor Of Differentiation 2 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Dna-Binding Protein Inhibitor Id-2 proteinClass B Basic Helix-Loop-Helix Protein 26 proteinBhlhb26 proteinInhibitor Of Dna Binding 2 proteinInhibitor Of Differentiation 2 proteinID2 proteinBHLHB26 protein |
Information sourced from Uniprot.org