Human ICT1 protein (Recombinant) (His-Tag) (STJP017941)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ICT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRPL58 |
| Gene ID | 3396 |
| Uniprot ID | ICT1_HUMAN |
| Accession Number | NP_001536 |
| Immunogen | Human |
| Immunogen Region | 30-206aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSLHKQKDG TEFKSIYSLD KLYPESQGSD TAWRVPNGAK QADSDIPLDR LTISYCRSSG PGGQNVNKVN SKAEVRFHLA TAEWIAEPVR QKIAITHKNK INRLGELILT SESSRYQFRN LADCLQKIRD MITEASQTPK EPTKEDVKLH RIRIENMNRE RLRQKRIHSA VKTSRRVDMD |
Additional Info
| Tissue Specificity | Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells. |
| Post Translational Modifications | Methylation of glutamine in the GGQ triplet by HEMK1. |
| Function | Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. |
| Protein Name | Large Ribosomal Subunit Protein Ml6239s Ribosomal Protein L58 - MitochondrialMrp-L58Digestion Substraction 1Ds-1Immature Colon Carcinoma Transcript 1 ProteinPeptidyl-Trna Hydrolase Ict1 - Mitochondrial |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Large Ribosomal Subunit Protein Ml62 protein39s Ribosomal Protein L58 - Mitochondrial proteinMrp-L58 proteinDigestion Substraction 1 proteinDs-1 proteinImmature Colon Carcinoma Transcript 1 Protein proteinPeptidyl-Trna Hydrolase Ict1 - Mitochondrial proteinMRPL58 proteinDS1 proteinICT1 protein |
Information sourced from Uniprot.org