| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA.Immobilized APC Mouse Anti-Human CD54 at 1 Mu g/mL (25 Mu L/well) can bind Human CD54 with a linear range of 0.46-7.8 ng/mL. |
| Gene Symbol: |
ICAM1 |
| Gene ID: |
3383 |
| Uniprot ID: |
ICAM1_HUMAN |
| Immunogen: |
Recombinant Human ICAM-1/CD54 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln28-Glu480) of human ICAM-1/CD54 (Accession #NP_000192.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
QTSVSPSKVILPRGGSVLVT CSTSCDQPKLLGIETPLPKK ELLLPGNNRKVYELSNVQED SQPMCYSNCPDGQSTAKTFL TVYWTPERVELAPLPSWQPV GKNLTLRCQVEGGAPRANLT VVLLRGEKELKREPAVGEPA EVTTTVLVRRDHHGANFSCR TELDLRPQGLELFENTSAPY QLQTFVLPATPPQLVSPRVL EVDTQGTVVCSLDGLFPVSE AQVHLALGDQRLNPTVTYG |
| Post Translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. |
| Protein Name | Intercellular Adhesion Molecule 1Icam-1Major Group Rhinovirus ReceptorCd Antigen Cd54 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-877300 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Intercellular Adhesion Molecule 1 proteinIcam-1 proteinMajor Group Rhinovirus Receptor proteinCd Antigen Cd54 proteinICAM1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
