Human IBSP protein (Recombinant-Active) (C-10*His) (STJP011921)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human IBSP-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by the ability of the Immobilised protein to support the adhesion of the human breast cancer cells (MCF‑7). The ED50 of this effect is 0.06-0.6 Mu g/mL. |
Target Information
| Gene Symbol | IBSP |
| Gene ID | 3381 |
| Uniprot ID | SIAL_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe17-Gln317 |
Additional Info
| Post Translational Modifications | N-glycosylated.glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains. O-glycosylated at eight sites.mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. |
| Function | Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3). |
| Protein Name | Integrin-Binding SialoproteinBone Sialoprotein 2Bone Sialoprotein IiBsp IiCell-Binding Sialoprotein |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Integrin-Binding SialoproteinBone Sialoprotein 2 proteinBone Sialoprotein Ii proteinBsp Ii proteinCell-Binding SialoproteinIBSP proteinBNSP protein |
Information sourced from Uniprot.org