Human Hydroxyacid Oxidase-1/HAO-1 protein (Recombinant) (His-Tag) (STJP017298)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Hydroxyacid Oxidase-1/HAO-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.5M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAO1 |
| Gene ID | 54363 |
| Uniprot ID | HAOX1_HUMAN |
| Accession Number | NP_060015 |
| Immunogen | Human |
| Immunogen Region | 1-370aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Highly expressed in liver. |
| Function | Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate. The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine.this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones. Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on L-lactate and 2-hydroxybutanoate. |
| Protein Name | 2-Hydroxyacid Oxidase 1Haox1Glycolate OxidaseGoGoxGlyoxylate Oxidase |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome Matrix |
| Alternative Protein Names | 2-Hydroxyacid Oxidase 1 proteinHaox1 proteinGlycolate Oxidase proteinGo proteinGox proteinGlyoxylate Oxidase proteinHAO1 proteinGOX1 protein |
Information sourced from Uniprot.org