Human HTRA2 protein (Recombinant) (C-His) (STJP012982)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HTRA2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 4mM HCl. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | HTRA2 |
| Gene ID | 27429 |
| Uniprot ID | HTRA2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala134-Glu458 |
Additional Info
| Post Translational Modifications | Ubiquitinated by BIRC6.this activity is inhibited by DIABLO/SMAC. Autoproteolytically activated. |
| Function | Isoform 1: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity.or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2: Seems to be proteolytically inactive. |
| Protein Name | Serine Protease Htra2 - MitochondrialHigh Temperature Requirement Protein A2Htra2Omi Stress-Regulated EndoproteaseSerine Protease 25Serine Proteinase Omi |
| Database Links | Reactome: R-HSA-9837999Reactome: R-HSA-9841251 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MembraneSingle-Pass Membrane ProteinPredominantly Present In The Intermembrane SpaceReleased Into The Cytosol Following Apoptotic StimuliSuch As Uv TreatmentAnd Stimulation Of Mitochondria With Caspase-8 Truncated Bid/TbidIsoform 1: Endoplasmic Reticulum |
| Alternative Protein Names | Serine Protease Htra2 - Mitochondrial proteinHigh Temperature Requirement Protein A2 proteinHtra2 proteinOmi Stress-Regulated Endoprotease proteinSerine Protease 25 proteinSerine Proteinase Omi proteinHTRA2 proteinOMI proteinPRSS25 protein |
Information sourced from Uniprot.org