Human HTRA1 protein (Recombinant) (N-His) (STJP005786)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HTRA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HTRA1 |
| Gene ID | 5654 |
| Uniprot ID | HTRA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly204-Leu364 |
Additional Info
| Function | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
| Protein Name | Serine Protease Htra1High-Temperature Requirement A Serine Peptidase 1L56Serine Protease 11 |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | Cell MembraneSecretedCytoplasmCytosolPredominantly SecretedAlso Found Associated With The Plasma Membrane |
| Alternative Protein Names | Serine Protease Htra1 proteinHigh-Temperature Requirement A Serine Peptidase 1 proteinL56 proteinSerine Protease 11 proteinHTRA1 proteinHTRA proteinPRSS11 protein |
Information sourced from Uniprot.org