Human HTR4 (5-Hydroxytryptamine Receptor 4) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015985)
SPECIFICATIONS
General Information
| Short Description | This HTR4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.063ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | HTR4 |
| Gene ID | 3360 |
| Uniprot ID | 5HT4R_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Isoform 5-HT4(A): Expressed in ileum, brain, and atrium, but not in the ventricle. Isoform 5-HT4(E): Mainly expressed in atria and cardiac ventricle. Isoform 5-HT4(I): Expressed in all cardiovascular tissues analyzed. |
| Post Translational Modifications | |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. |
| Protein Name | 5-Hydroxytryptamine Receptor 45-Ht-45-Ht4Serotonin Receptor 4 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome MembraneInteraction With Snx27 Mediates Recruitment To Early EndosomesWhile Interaction With Nherf1 And Ezr Might Target The Protein To Specialized Subcellular RegionsSuch As Microvilli |
| Alternative ELISA Names | 5-Hydroxytryptamine Receptor 4 ELISA kit5-Ht-4 ELISA kit5-Ht4 ELISA kitSerotonin Receptor 4 ELISA kitHTR4 ELISA kit |
| output |
Information sourced from Uniprot.org