Human HTR1A (5-Hydroxytryptamine Receptor 1A) Sandwich ELISA Kit (STJE0009597)
SPECIFICATIONS
General Information
| Short Description | This HTR1A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.059ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | HTR1A |
| Gene ID | 3350 |
| Uniprot ID | 5HT1A_HUMAN |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. |
| Post Translational Modifications | |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. |
| Protein Name | 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aG-21Serotonin Receptor 1a |
| Database Links | Reactome: R-HSA-390666 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative ELISA Names | 5-Hydroxytryptamine Receptor 1a ELISA kit5-Ht-1a ELISA kit5-Ht1a ELISA kitG-21 ELISA kitSerotonin Receptor 1a ELISA kitHTR1A ELISA kitADRB2RL1 ELISA kitADRBRL1 ELISA kit |
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Information sourced from Uniprot.org