Human HSPH1 protein (Recombinant) (His-Tag) (STJP019665)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HSPH1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 50mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSPH1 |
| Gene ID | 10808 |
| Uniprot ID | HS105_HUMAN |
| Accession Number | NP_006635.2 |
| Immunogen | Human |
| Immunogen Region | 1-858aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. |
| Post Translational Modifications | Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |
| Function | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. |
| Protein Name | Heat Shock Protein 105 KdaAntigen Ny-Co-25Heat Shock 110 Kda ProteinHeat Shock Protein Family H Member 1 |
| Database Links | Reactome: R-HSA-3000484Reactome: R-HSA-3371453 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Heat Shock Protein 105 Kda proteinAntigen Ny-Co-25 proteinHeat Shock 110 Kda Protein proteinHeat Shock Protein Family H Member 1 proteinHSPH1 proteinHSP105 proteinHSP110 proteinKIAA0201 protein |
Information sourced from Uniprot.org