SDS-PAGE of recombinant human HSPB11 protein under reducing conditions Coomassie blue stain

Human HSPB11 protein (Recombinant) (His-Tag) (STJP017196)

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STJP017196
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Short Description :Recombinant-Human HSPB11-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl.
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:IFT25
Gene ID:51668
Uniprot ID:IFT25_HUMAN
Accession Number:NP_057210
Immunogen:Human
Immunogen Region:1-144aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI ICFHKHVRIE RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL QNEEIVAHDG SATYLRFIIV SAFDHFASVH SVSAEGTVVS NLSS
Tissue Specificity Detected in placenta.
Function Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.
Protein Name Intraflagellar Transport Protein 25 Homolog
Heat Shock Protein Beta-11
Hspb11
Heat Shock Protein Family B Member 11
Placental Protein 25
Pp25
Database Links Reactome: R-HSA-5620924
Cellular Localisation Cell Projection
Cilium
Alternative Protein Names Intraflagellar Transport Protein 25 Homolog protein
Heat Shock Protein Beta-11 protein
Hspb11 protein
Heat Shock Protein Family B Member 11 protein
Placental Protein 25 protein
Pp25 protein
IFT25 protein
C1orf41 protein
HSPB11 protein
HSPC034 protein

Information sourced from Uniprot.org

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