Human HSP90B1 protein (Recombinant) (N-His) (STJP004102)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HSP90B1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HSP90B1 |
| Gene ID | 7184 |
| Uniprot ID | ENPL_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp22-Ala311 |
Additional Info
| Function | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion.the translocation process is mediated by the cargo receptor TMED10. |
| Protein Name | Endoplasmin94 Kda Glucose-Regulated ProteinGrp-94Heat Shock Protein 90 Kda Beta Member 1Heat Shock Protein Family C Member 4Tumor Rejection Antigen 1Gp96 Homolog |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-3000480Reactome: R-HSA-381183Reactome: R-HSA-381426Reactome: R-HSA-6785807Reactome: R-HSA-8957275 |
| Cellular Localisation | Endoplasmic Reticulum LumenSarcoplasmic Reticulum LumenMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Protein Names | Endoplasmin protein94 Kda Glucose-Regulated Protein proteinGrp-94 proteinHeat Shock Protein 90 Kda Beta Member 1 proteinHeat Shock Protein Family C Member 4 proteinTumor Rejection Antigen 1 proteinGp96 Homolog proteinHSP90B1 proteinGRP94 proteinHSPC4 proteinTRA1 protein |
Information sourced from Uniprot.org