Human HSD17B3 protein (Recombinant) (N-His) (STJP006615)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HSD17B3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HSD17B3 |
| Gene ID | 3293 |
| Uniprot ID | DHB3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg310 |
Additional Info
| Function | Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms. |
| Protein Name | 17-Beta-Hydroxysteroid Dehydrogenase Type 317-Beta-Hsd 3Estradiol 17-Beta-Dehydrogenase 2Short Chain Dehydrogenase/Reductase Family 12c Member 2Testicular 17-Beta-Hydroxysteroid DehydrogenaseTestosterone 17-Beta-Dehydrogenase 3 |
| Database Links | Reactome: R-HSA-193048Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum |
| Alternative Protein Names | 17-Beta-Hydroxysteroid Dehydrogenase Type 3 protein17-Beta-Hsd 3 proteinEstradiol 17-Beta-Dehydrogenase 2 proteinShort Chain Dehydrogenase/Reductase Family 12c Member 2 proteinTesticular 17-Beta-Hydroxysteroid Dehydrogenase proteinTestosterone 17-Beta-Dehydrogenase 3 proteinHSD17B3 proteinEDH17B3 proteinSDR12C2 protein |
Information sourced from Uniprot.org