Human HSD17B12 protein (Recombinant) (N-His) (STJP010939)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HSD17B12-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HSD17B12 |
| Gene ID | 51144 |
| Uniprot ID | DHB12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser27-Lys181 |
Additional Info
| Function | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. |
| Protein Name | Very-Long-Chain 3-Oxoacyl-Coa Reductase17-Beta-Hydroxysteroid Dehydrogenase 1217-Beta-Hsd 123-Ketoacyl-Coa ReductaseKarEstradiol 17-Beta-Dehydrogenase 12Short Chain Dehydrogenase/Reductase Family 12c Member 1 |
| Database Links | Reactome: R-HSA-193048Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Very-Long-Chain 3-Oxoacyl-Coa Reductase protein17-Beta-Hydroxysteroid Dehydrogenase 12 protein17-Beta-Hsd 12 protein3-Ketoacyl-Coa Reductase proteinKar proteinEstradiol 17-Beta-Dehydrogenase 12 proteinShort Chain Dehydrogenase/Reductase Family 12c Member 1 proteinHSD17B12 proteinSDR12C1 protein |
Information sourced from Uniprot.org