Human HSD11B2 protein (Recombinant) (N-His) (STJP006641)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HSD11B2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HSD11B2 |
| Gene ID | 3291 |
| Uniprot ID | DHI2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly106-Arg405 |
Additional Info
| Function | Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration. May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol. |
| Protein Name | 11-Beta-Hydroxysteroid Dehydrogenase Type 211-Dh211-Beta-Hsd211-Beta-Hydroxysteroid Dehydrogenase Type Ii11-Hsd Type Ii11-Beta-Hsd Type IiCorticosteroid 11-Beta-Dehydrogenase Isozyme 2Nad-Dependent 11-Beta-Hydroxysteroid DehydrogenaseShort Chain Dehydrogenase/Reductase Family 9c Member 3 |
| Database Links | Reactome: R-HSA-194002Reactome: R-HSA-9757110 |
| Cellular Localisation | MicrosomeEndoplasmic Reticulum |
| Alternative Protein Names | 11-Beta-Hydroxysteroid Dehydrogenase Type 2 protein11-Dh2 protein11-Beta-Hsd2 protein11-Beta-Hydroxysteroid Dehydrogenase Type Ii protein11-Hsd Type Ii protein11-Beta-Hsd Type Ii proteinCorticosteroid 11-Beta-Dehydrogenase Isozyme 2 proteinNad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase proteinShort Chain Dehydrogenase/Reductase Family 9c Member 3 proteinHSD11B2 proteinHSD11K proteinSDR9C3 protein |
Information sourced from Uniprot.org