| Tissue Specificity | Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. |
| Protein Name | Heparan Sulfate Glucosamine 3-O-Sulfotransferase 1Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 13-Ost-1Heparan Sulfate 3-O-Sulfotransferase 1H3-Ost-1 |
| Database Links | Reactome: R-HSA-2022928 |
| Cellular Localisation | Golgi Apparatus Lumen |
| Alternative Protein Names | Heparan Sulfate Glucosamine 3-O-Sulfotransferase 1 proteinHeparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 1 protein3-Ost-1 proteinHeparan Sulfate 3-O-Sulfotransferase 1 proteinH3-Ost-1 proteinHS3ST1 protein3OST protein3OST1 protein |
Information sourced from Uniprot.org