Human HS3ST1 protein (Recombinant) (His-Tag) (STJP018423)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HS3ST1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HS3ST1 |
| Gene ID | 9957 |
| Uniprot ID | HS3S1_HUMAN |
| Accession Number | NP_005105 |
| Immunogen | Human |
| Immunogen Region | 21-307aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSRPAELGQ QELLRKAGTL QDDVRDGVAP NGSAQQLPQT IIIGVRKGGT RALLEMLSLH PDVAAAENEV HFFDWEEHYS HGLGWYLSQM PFSWPHQLTV EKTPAYFTSP KVPERVYSMN PSIRLLLILR DPSERVLSDY TQVFYNHMQK HKPYPSIEEF LVRDGRLNVD YKALNRSLYH VHMQNWLRFF PLRHIHIVDG DRLIRDPF |
Additional Info
| Tissue Specificity | Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. |
| Protein Name | Heparan Sulfate Glucosamine 3-O-Sulfotransferase 1Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 13-Ost-1Heparan Sulfate 3-O-Sulfotransferase 1H3-Ost-1 |
| Database Links | Reactome: R-HSA-2022928 |
| Cellular Localisation | Golgi Apparatus Lumen |
| Alternative Protein Names | Heparan Sulfate Glucosamine 3-O-Sulfotransferase 1 proteinHeparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 1 protein3-Ost-1 proteinHeparan Sulfate 3-O-Sulfotransferase 1 proteinH3-Ost-1 proteinHS3ST1 protein3OST protein3OST1 protein |
Information sourced from Uniprot.org