Human HORMAD1 protein (Recombinant) (N-His) (STJP008349)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HORMAD1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HORMAD1 |
| Gene ID | 84072 |
| Uniprot ID | HORM1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser21-Arg232 |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-377 in a SPO11-dependent manner. |
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. |
| Protein Name | Horma Domain-Containing Protein 1Cancer/Testis Antigen 46Ct46Newborn Ovary Horma Protein |
| Database Links | |
| Cellular Localisation | NucleusChromosomePreferentially Localizes To Unsynapsed Or Desynapsed Chromosomal Regions During The Prophase I Stage Of MeiosisTrip13 Is Required For Depletion From Synapsed ChromosomesThe Expression Of The Phosphorylated Form At Ser-377 Is Restricted To Unsynapsed Chromosomal Regions |
| Alternative Protein Names | Horma Domain-Containing Protein 1 proteinCancer/Testis Antigen 46 proteinCt46 proteinNewborn Ovary Horma Protein proteinHORMAD1 proteinNOHMA protein |
Information sourced from Uniprot.org