| Post Translational Modifications | A soluble form arises by proteolytic removal of the membrane anchor. |
| Function | Heme oxygenase 1: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis. Heme oxygenase 1: (Microbial infection) During SARS-COV-2 infection, promotes SARS-CoV-2 ORF3A-mediated autophagy but is unlikely to be required for ORF3A-mediated induction of reticulophagy. Heme oxygenase 1 soluble form: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
| Protein Name | Heme Oxygenase 1Ho-1 Cleaved Into - Heme Oxygenase 1 Soluble Form |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-6785807Reactome: R-HSA-844456Reactome: R-HSA-917937Reactome: R-HSA-9609523Reactome: R-HSA-9660826Reactome: R-HSA-9707564Reactome: R-HSA-9707587Reactome: R-HSA-9707616Reactome: R-HSA-9818027 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCytoplasmic Side |
| Alternative Antibody Pair Names | Heme Oxygenase 1 antibody pairHo-1 Cleaved Into - Heme Oxygenase 1 Soluble Form antibody pairHMOX1 antibody pairHO antibody pairHO1 antibody pair |
Information sourced from Uniprot.org
