Human HNRNPC protein (Recombinant) (His-Tag) (STJP017102)

Name: Human HNRNPC protein (Recombinant) (His-Tag) (STJP017102)
SKU: STJP017102
Availability: InStock

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SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017102

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Short Description	Recombinant-Human HNRNPC-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.25 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 30% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	HNRNPC
Gene ID	3183
Uniprot ID	HNRPC_HUMAN
Accession Number	NP_004491
Immunogen	Human
Immunogen Region	1-293aa
Immunogen Sequence	MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS KSGKLKGDDL QAIKKELTQI KQKVDSLLEN LEKIEK

Post Translational Modifications	Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide. Sumoylated. Sumoylation reduces affinity for mRNA. Ubiquitinated and degraded after nucleo-cytoplasmic transport by YWHAE.
Function	Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Protein Name	Heterogeneous Nuclear Ribonucleoproteins C1/C2 Hnrnp C1/C2
Database Links	Reactome: R-HSA-4570464 Reactome: R-HSA-72163 Reactome: R-HSA-72203 Reactome: R-HSA-9013418 Reactome: R-HSA-9013422
Cellular Localisation	Nucleus Component Of Ribonucleosomes
Alternative Protein Names	Heterogeneous Nuclear Ribonucleoproteins C1/C2 protein Hnrnp C1/C2 protein HNRNPC protein HNRPC protein

Information sourced from Uniprot.org