Human HMGN3 protein (Recombinant) (His-Tag) (STJP018892)

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STJP018892
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HMGN3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH7.0) containing 10% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HMGN3
Gene ID: 9324
Uniprot ID: HMGN3_HUMAN
Immunogen Region: 1-77aa
Accession Number: NP_620058
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN
Tissue Specificity Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
Function Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
Protein Name High Mobility Group Nucleosome-Binding Domain-Containing Protein 3
Thyroid Receptor-Interacting Protein 7
Tr-Interacting Protein 7
Trip-7
Database Links
Cellular Localisation Nucleus
Alternative Protein Names High Mobility Group Nucleosome-Binding Domain-Containing Protein 3 protein
Thyroid Receptor-Interacting Protein 7 protein
Tr-Interacting Protein 7 protein
Trip-7 protein
HMGN3 protein
TRIP7 protein
PNAS-24 protein

Information sourced from Uniprot.org

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