Human HMGN3 protein (Recombinant) (His-Tag) (STJP018892)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HMGN3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH7.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMGN3 |
| Gene ID | 9324 |
| Uniprot ID | HMGN3_HUMAN |
| Accession Number | NP_620058 |
| Immunogen | Human |
| Immunogen Region | 1-77aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN |
Additional Info
| Tissue Specificity | Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. |
| Function | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. |
| Protein Name | High Mobility Group Nucleosome-Binding Domain-Containing Protein 3Thyroid Receptor-Interacting Protein 7Tr-Interacting Protein 7Trip-7 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | High Mobility Group Nucleosome-Binding Domain-Containing Protein 3 proteinThyroid Receptor-Interacting Protein 7 proteinTr-Interacting Protein 7 proteinTrip-7 proteinHMGN3 proteinTRIP7 proteinPNAS-24 protein |
Information sourced from Uniprot.org