Human HMBS (Hydroxymethylbilane Synthase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015850)

Name: Human HMBS (Hydroxymethylbilane Synthase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015850)
SKU: STJE0015850
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

STJE0015850

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Short Description	This HMBS Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Applications	ELISA
Reactivity	Human
Sensitivity	0.27ng/mL
Detection Limit	0.781-50ng/mL
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Storage Instruction	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time	3 hrs

Gene Symbol	HMBS
Gene ID	3145
Uniprot ID	HEM3_HUMAN
Immunogen Region	Ready-To-Use
Sample Type	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Isoform 1: Is ubiquitously expressed. Isoform 2: Is found only in erythroid cells.
Post Translational Modifications
Function	As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.
Protein Name	Porphobilinogen Deaminase Pbg-D Hydroxymethylbilane Synthase Hmbs Pre-Uroporphyrinogen Synthase
Database Links	Reactome: R-HSA-189451
Cellular Localisation	Cytoplasm Cytosol
Alternative ELISA Names	Porphobilinogen Deaminase ELISA kit Pbg-D ELISA kit Hydroxymethylbilane Synthase ELISA kit Hmbs ELISA kit Pre-Uroporphyrinogen Synthase ELISA kit HMBS ELISA kit PBGD ELISA kit UPS ELISA kit
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Information sourced from Uniprot.org