Human HHEX protein (Recombinant) (His-Tag) (STJP018344)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HHEX-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 40% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HHEX |
| Gene ID | 3087 |
| Uniprot ID | HHEX_HUMAN |
| Accession Number | NP_002720 |
| Immunogen | Human |
| Immunogen Region | 1-270aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Liver and promyelocytic leukemia cell line HL-60. |
| Function | Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Activator of WNT-mediated transcription in conjunction with CTNNB1. Establishes anterior identity at two levels.acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. Inhibits EIF4E-mediated mRNA nuclear export. May play a role in hematopoietic differentiation. |
| Protein Name | Hematopoietically-Expressed Homeobox Protein HhexHomeobox Protein HexHomeobox Protein PrhProline-Rich Homeodomain Protein |
| Database Links | Reactome: R-HSA-9925561 |
| Cellular Localisation | NucleusNuclear BodyCytoplasm |
| Alternative Protein Names | Hematopoietically-Expressed Homeobox Protein Hhex proteinHomeobox Protein Hex proteinHomeobox Protein Prh proteinProline-Rich Homeodomain Protein proteinHHEX proteinHEX proteinPRH proteinPRHX protein |
Information sourced from Uniprot.org