Human HGF Activator/HGFA protein (Recombinant) (C-6His) (STJP020374)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human HGF Activator/HGFA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln36-Ser655) of Human HGF Activator/HGFA (Accession #NP_001519.1) fused with His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human HGF Activator/HGFA-C-6His protein was developed in hek293 cells using the region Gln36-Ser655. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method |
Target Information
| Gene Symbol | HGFAC |
| Gene ID | 3083 |
| Uniprot ID | HGFA_HUMAN |
| Immunogen | Recombinant Human HGF Activator/HGFA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln36-Ser655) of Human HGF Activator/HGFA (Accession #NP_001519.1) fused with His tag at the C-terminus. |
| Immunogen Region | Gln36-Ser655 |
| Immunogen Sequence | QPGGNRTESPEPNATATPAI PTILVTSVTSETPATSAPEA EGPQSGGLPPPPRAVPSSSS PQAQALTEDGRPCRFPFRYG GRMLHACTSEGSAHRKWCAT THNYDRDRAWGYCVEATPPP GGPAALDPCASGPCLNGGSC SNTQDPQSYHCSCPRAFTGK DCGTEKCFDETRYEYLEGGD RWARVRQGHVEQCECFGGRT WCEGTRHTACLSSPCLNGGT CHLIVATGTTVCACPPGFA |
Additional Info
| Tissue Specificity | Liver. |
| Post Translational Modifications | The active form of HGFAC presents in the serum is derived from the COOH-terminal region of the precursor by the cleavage of bonds between Arg-372 and Val-373 and Arg-407 and Ile-408. |
| Function | Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway. |
| Protein Name | Hepatocyte Growth Factor Activator Serine ProteaseHgf ActivatorHgfaHgfa Serine ProteaseSerine Protease Hgfac Cleaved Into - Hepatocyte Growth Factor Activator Short Chain - Hepatocyte Growth Factor Activator Long Chain |
| Database Links | Reactome: R-HSA-6806942 |
| Cellular Localisation | SecretedExists As An Inactive Zymogen In PlasmaExists As An Active Heterodimeric Form In Serum |
| Alternative Protein Names | Hepatocyte Growth Factor Activator Serine Protease proteinHgf Activator proteinHgfa proteinHgfa Serine Protease proteinSerine Protease Hgfac Cleaved Into - Hepatocyte Growth Factor Activator Short Chain - Hepatocyte Growth Factor Activator Long Chain proteinHGFAC protein |
Information sourced from Uniprot.org