Human HEXIM1 protein (Recombinant) (N-His) (STJP015213)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HEXIM1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | HEXIM1 |
| Gene ID | 10614 |
| Uniprot ID | HEXI1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr171-Asp359 |
Additional Info
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
| Alternative Protein Names | Protein Hexim1 proteinCardiac Lineage Protein 1 proteinEstrogen Down-Regulated Gene 1 Protein proteinHexamethylene Bis-Acetamide-Inducible Protein 1 proteinMenage A Quatre Protein 1 proteinHEXIM1 proteinCLP1 proteinEDG1 proteinHIS1 proteinMAQ1 protein |
Information sourced from Uniprot.org