Human HEXIM1 protein (Recombinant) (His-Tag) (STJP016616)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HEXIM1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEXIM1 |
| Gene ID | 10614 |
| Uniprot ID | HEXI1_HUMAN |
| Accession Number | NP_006451.1 |
| Immunogen | Human |
| Immunogen Region | 1-359aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
| Alternative Protein Names | Protein Hexim1 proteinCardiac Lineage Protein 1 proteinEstrogen Down-Regulated Gene 1 Protein proteinHexamethylene Bis-Acetamide-Inducible Protein 1 proteinMenage A Quatre Protein 1 proteinHEXIM1 proteinCLP1 proteinEDG1 proteinHIS1 proteinMAQ1 protein |
Information sourced from Uniprot.org