Human HEXB protein (Recombinant) (N-His) (STJP003800)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HEXB-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HEXB |
| Gene ID | 3074 |
| Uniprot ID | HEXB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys315-Tyr456 |
Additional Info
| Function | Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida. |
| Protein Name | Beta-Hexosaminidase Subunit BetaBeta-N-Acetylhexosaminidase Subunit BetaHexosaminidase Subunit BCervical Cancer Proto-Oncogene 7 ProteinHcc-7N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2024101Reactome: R-HSA-2160916Reactome: R-HSA-3656248Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | LysosomeCytoplasmic VesicleSecretory VesicleCortical Granule |
| Alternative Protein Names | Beta-Hexosaminidase Subunit Beta proteinBeta-N-Acetylhexosaminidase Subunit Beta proteinHexosaminidase Subunit B proteinCervical Cancer Proto-Oncogene 7 Protein proteinHcc-7 proteinN-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A proteinHEXB proteinHCC7 protein |
Information sourced from Uniprot.org