Human HEPACAM2 protein (Recombinant) (His-Tag) (STJP018391)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HEPACAM2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HEPACAM2 |
| Gene ID | 253012 |
| Uniprot ID | HECA2_HUMAN |
| Accession Number | NP_001034461 |
| Immunogen | Human |
| Immunogen Region | 32-351aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSLKVTVPS HTVHGVRGQA LYLPVHYGFH TPASDIQIIW LFERPHTMPK YLLGSVNKSV VPDLEYQHKF TMMPPNASLL INPLQFPDEG NYIVKVNIQG NGTLSASQKI QVTVDDPVTK PVVQIHPPSG AVEYVGNMTL TCHVEGGTRL AYQWLKNGRP VHTSSTYSFS PQNNTLHIAP VTKEDIGNYS CLVRNPVSEM ESDIIMPI |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes. N-glycosylated. |
| Function | Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. |
| Protein Name | Hepacam Family Member 2Mitotic Kinetics Regulator |
| Database Links | |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinCytoplasmCytoskeletonSpindleMicrotubule Organizing CenterCentrosomeMidbodyIn InterphaseLocalizes To The Golgi ApparatusLocalizes To Centrosomes And Spindles During ProphasePrometaphaseAnd Metaphase Of MitosisAnd To Midbodies At TelophaseTranslocation To Mitotic Centrosomes Is The Result Of Poly-Adp-Ribosylation (Parsylation) |
| Alternative Protein Names | Hepacam Family Member 2 proteinMitotic Kinetics Regulator proteinHEPACAM2 proteinMIKI proteinUNQ305 proteinPRO346 protein |
Information sourced from Uniprot.org