Tissue Specificity | Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. |
Post Translational Modifications | |
Function | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). |
Protein Name | HemogenErythroid Differentiation-Associated Gene ProteinEdag-1Hemopoietic Gene ProteinNegative Differentiation Regulator Protein |
Database Links | |
Cellular Localisation | Nucleus |
Alternative ELISA Names | Hemogen ELISA kitErythroid Differentiation-Associated Gene Protein ELISA kitEdag-1 ELISA kitHemopoietic Gene Protein ELISA kitNegative Differentiation Regulator Protein ELISA kitHEMGN ELISA kitEDAG ELISA kitNDR ELISA kitPRO1037 ELISA kitPRO1620 ELISA kit |
output | |
Information sourced from Uniprot.org