Human Hematopoietic Prostaglandin D Synthase/HPGDS protein (Recombinant) (His-Tag) (STJP017667)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Hematopoietic Prostaglandin D Synthase/HPGDS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.15M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HPGDS |
| Gene ID | 27306 |
| Uniprot ID | HPGDS_HUMAN |
| Accession Number | NP_055300 |
| Immunogen | Human |
| Immunogen Region | 1-199aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. |
| Function | Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. |
| Protein Name | Hematopoietic Prostaglandin D SynthaseH-PgdsGst Class-SigmaGlutathione S-TransferaseGlutathione-Dependent Pgd SynthaseGlutathione-Requiring Prostaglandin D SynthaseProstaglandin-H2 D-Isomerase |
| Database Links | Reactome: R-HSA-156590Reactome: R-HSA-2162123 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Hematopoietic Prostaglandin D Synthase proteinH-Pgds proteinGst Class-Sigma proteinGlutathione S-Transferase proteinGlutathione-Dependent Pgd Synthase proteinGlutathione-Requiring Prostaglandin D Synthase proteinProstaglandin-H2 D-Isomerase proteinHPGDS proteinGSTS proteinPGDS proteinPTGDS2 protein |
Information sourced from Uniprot.org