Human Hedgehog-interacting protein/HHIP protein (Recombinant) (C-His) (STJP000999)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Hedgehog-interacting protein/HHIP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe18-Asp670) of human Hip (Accession #NP_071920.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Hedgehog-interacting protein/HHIP-C-His protein was developed in hek293 cells using the region Phe18-Asp670. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | HHIP |
| Gene ID | 64399 |
| Uniprot ID | HHIP_HUMAN |
| Immunogen | Recombinant Human Hedgehog-interacting protein/HHIP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe18-Asp670) of human Hip (Accession #NP_071920.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Phe18-Asp670 |
| Immunogen Sequence | FFEGDAKFGERNEGSGARRR RCLNGNPPKRLKRRDRRMMS QLELLSGGEMLCGGFYPRLS CCLRSDSPGLGRLENKIFSV TNNTECGKLLEEIKCALCSP HSQSLFHSPEREVLERDLVL PLLCKDYCKEFFYTCRGHIP GFLQTTADEFCFYYARKDGG LCFPDFPRKQVRGPASNYLD QMEEYDKVEEISRKHKHNCF CIQEVVSGLRQPVGALHSGD GSQRLFILEKEGYVKILTP |
Additional Info
| Tissue Specificity | Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. |
| Function | Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. |
| Protein Name | Hedgehog-Interacting ProteinHhipHip |
| Database Links | Reactome: R-HSA-5632681 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinSecretedThe Last 22 C-Terminal Amino Acids May Participate In Cell Membrane AttachmentIsoform 2: Cytoplasm |
| Alternative Protein Names | Hedgehog-Interacting Protein proteinHhip proteinHip proteinHHIP proteinHIP proteinUNQ5825 proteinPRO19644 protein |
Information sourced from Uniprot.org