Human HCVADR/CXADR protein (Recombinant) (C-hFc&His) (STJP001007)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human HCVADR/CXADR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu20-Gly237) of human CXADR/CAR (Accession #NP_001329.1) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human HCVADR/CXADR-C-hFc&His protein was developed in hek293 cells using the region Leu20-Gly237. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CXADR |
| Gene ID | 1525 |
| Uniprot ID | CXAR_HUMAN |
| Immunogen | Recombinant Human HCVADR/CXADR Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu20-Gly237) of human CXADR/CAR (Accession #NP_001329.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Leu20-Gly237 |
| Immunogen Sequence | LSITTPEEMIEKAKGETAYL PCKFTLSPEDQGPLDIEWLI SPADNQKVDQVIILYSGDKI YDDYYPDLKGRVHFTSNDLK SGDASINVTNLQLSDIGTYQ CKVKKAPGVANKKIHLVVLV KPSGARCYVDGSEEIGSDFK IKCEPKEGSLPLQYEWQKLS DSQKMPTSWLAEMTSSVISV KNASSEYSGTYSCTVRNRVG SDQCLLRLNVVPPSNKAG |
Additional Info
| Tissue Specificity | Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. |
| Post Translational Modifications | N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane. |
| Function | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. |
| Protein Name | Coxsackievirus And Adenovirus ReceptorCarHcarCvb3-Binding ProteinCoxsackievirus B-Adenovirus ReceptorHcvadr |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneCell JunctionTight JunctionAdherens JunctionIn Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens JunctionsIn Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical SurfaceIsoform 3: SecretedIsoform 4: SecretedIsoform 5: Secreted |
| Alternative Protein Names | Coxsackievirus And Adenovirus Receptor proteinCar proteinHcar proteinCvb3-Binding Protein proteinCoxsackievirus B-Adenovirus Receptor proteinHcvadr proteinCXADR proteinCAR protein |
Information sourced from Uniprot.org