Human HAX-1 protein (Recombinant) (His-Tag) (STJP018076)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HAX-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAX1 |
| Gene ID | 10456 |
| Uniprot ID | HAX1_HUMAN |
| Accession Number | NP_006109 |
| Immunogen | Human |
| Immunogen Region | 1-279aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR TREDNDLDSQ VSQEGLGPVL QPQPKSYF |
Additional Info
| Tissue Specificity | Ubiquitous. Up-regulated in oral cancers. |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Protein Name | Hcls1-Associated Protein X-1Hs1-Associating Protein X-1Hax-1Hs1-Binding Protein 1Hsp1bp-1 |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixEndoplasmic ReticulumNucleus MembraneCytoplasmic VesicleCytoplasmCell CortexCell MembranePeripheral Membrane ProteinCytoplasmic SideSarcoplasmic ReticulumP-BodyIsoform 1: CytoplasmNucleusPredominantly CytoplasmicAlso Detected In The Nucleus When Nuclear Export Is InhibitedAnd In Response To Cellular Stress Caused By Arsenite (In Vitro)Isoform 3: CytoplasmAlso Detected In The Nucleus When Nuclear Export Is Inhibited (In Vitro)Isoform 4: CytoplasmShuttles Between Nucleus And CytoplasmIsoform 5: Cytoplasm |
| Alternative Protein Names | Hcls1-Associated Protein X-1 proteinHs1-Associating Protein X-1 proteinHax-1 proteinHs1-Binding Protein 1 proteinHsp1bp-1 proteinHAX1 proteinHS1BP1 protein |
Information sourced from Uniprot.org