Human Harmonin/USH1C protein (Recombinant) (His-Tag) (STJP016481)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Harmonin/USH1C-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USH1C |
| Gene ID | 10083 |
| Uniprot ID | USH1C_HUMAN |
| Accession Number | AAH16057 |
| Immunogen | Human |
| Immunogen Region | 1-533aa |
| Immunogen Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDR KVAREFRHKV DFLIENDAEK DYLYDVLRMY HQTMDVAVLV GDLKLVINEP SRLPLFDAIR PLIPLKHQVE YDQLTPRRSR KLKEVRLDRL HPEGLGLSVR GGLEFGCGLF ISHLIKGGQA DSVGLQVGDE IVRINGYSIS SCTHEEVINL IRTKKTVSIK VRHIGLIPVK SSPDEPLTWQ YVDQFVSE |
Additional Info
| Tissue Specificity | Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear. |
| Function | Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips. |
| Protein Name | HarmoninAntigen Ny-Co-38/Ny-Co-37Autoimmune Enteropathy-Related Antigen Aie-75Protein Pdz-73Renal Carcinoma Antigen Ny-Ren-3Usher Syndrome Type-1c Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell ProjectionMicrovillusColocalizes With F-ActinDetected At The Tip Of Cochlear Hair Cell StereociliaEnriched In Microvilli Of The Intestinal Brush Border |
| Alternative Protein Names | Harmonin proteinAntigen Ny-Co-38/Ny-Co-37 proteinAutoimmune Enteropathy-Related Antigen Aie-75 proteinProtein Pdz-73 proteinRenal Carcinoma Antigen Ny-Ren-3 proteinUsher Syndrome Type-1c Protein proteinUSH1C proteinAIE75 protein |
Information sourced from Uniprot.org