Human HAO1 protein (Recombinant) (N-Trx-His) (STJP014762)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HAO1-N-Trx-His protein was developed from e.coli and has a target region of N-Trx-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | HAO1 |
| Gene ID | 54363 |
| Uniprot ID | HAOX1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ile370 |
Additional Info
| Function | Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate. The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine.this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones. Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on L-lactate and 2-hydroxybutanoate. |
| Protein Name | 2-Hydroxyacid Oxidase 1Haox1Glycolate OxidaseGoGoxGlyoxylate Oxidase |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome Matrix |
| Alternative Protein Names | 2-Hydroxyacid Oxidase 1 proteinHaox1 proteinGlycolate Oxidase proteinGo proteinGox proteinGlyoxylate Oxidase proteinHAO1 proteinGOX1 protein |
Information sourced from Uniprot.org