Human HAND1 protein (Recombinant) (His-Tag) (STJP017847)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HAND1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HAND1 |
| Gene ID | 9421 |
| Uniprot ID | HAND1_HUMAN |
| Accession Number | NP_004812 |
| Immunogen | Human |
| Immunogen Region | 1-215aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMNLVGSY AHHHHHHHPH PAHPMLHEPF LFGPASRCHQ ERPYFQSWLL SPADAAPDFP AGGPPPAAAA AATAYGPDAR PGQSPGRLEA LGGRLGRRKG SGPKKERRRT ESINSAFAEL RECIPNVPAD TKLSKIKTLR LATSYIAYLM DVLAKDAQSG DPEAFKAELK KADGGRESKR KRELQQHEGF PPALGPVEKR IKGRTGWP |
Additional Info
| Tissue Specificity | Heart. |
| Post Translational Modifications | Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. |
| Function | Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes. |
| Protein Name | Heart- And Neural Crest Derivatives-Expressed Protein 1Class A Basic Helix-Loop-Helix Protein 27Bhlha27Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1Ehand |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusNucleoplasmNucleolusInteraction With Mdfic Sequesters It Into The NucleolusPreventing The Transcription Factor ActivityPhosphorylation By Plk4 Disrupts The Interaction With Mdfic And Releases It From The NucleolusLeading To Transcription Factor Activity |
| Alternative Protein Names | Heart- And Neural Crest Derivatives-Expressed Protein 1 proteinClass A Basic Helix-Loop-Helix Protein 27 proteinBhlha27 proteinExtraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1 proteinEhand proteinHAND1 proteinBHLHA27 proteinEHAND protein |
Information sourced from Uniprot.org