Human HAMP/Hepcidin protein (Recombinant) (N-GST) (STJP014588)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HAMP/Hepcidin-N-GST protein was developed from e.coli and has a target region of N-GST. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in PBS, 50% Glycerol, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | HAMP |
| Gene ID | 57817 |
| Uniprot ID | HEPC_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp60-Thr84 |
Additional Info
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. |
| Protein Name | HepcidinLiver-Expressed Antimicrobial Peptide 1Leap-1Putative Liver Tumor RegressorPltr Cleaved Into - Hepcidin-25Hepc25 - Hepcidin-20Hepc20 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Hepcidin proteinLiver-Expressed Antimicrobial Peptide 1 proteinLeap-1 proteinPutative Liver Tumor Regressor proteinPltr Cleaved Into - Hepcidin-25 proteinHepc25 - Hepcidin-20 proteinHepc20 proteinHAMP proteinHEPC proteinLEAP1 proteinUNQ487 proteinPRO1003 protein |
Information sourced from Uniprot.org