Human HADH protein (Recombinant) (N-His) (STJP005525)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human HADH-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | HADH |
| Gene ID | 3033 |
| Uniprot ID | HCDH_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg236 |
Additional Info
| Post Translational Modifications | Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. |
| Function | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes. |
| Protein Name | Hydroxyacyl-Coenzyme A Dehydrogenase - MitochondrialHcdhMedium And Short-Chain L-3-Hydroxyacyl-Coenzyme A DehydrogenaseShort-Chain 3-Hydroxyacyl-Coa Dehydrogenase |
| Database Links | Reactome: R-HSA-77310Reactome: R-HSA-77346Reactome: R-HSA-77348Reactome: R-HSA-77350Reactome: R-HSA-77352Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Hydroxyacyl-Coenzyme A Dehydrogenase - Mitochondrial proteinHcdh proteinMedium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase proteinShort-Chain 3-Hydroxyacyl-Coa Dehydrogenase proteinHADH proteinHAD proteinHAD1 proteinHADHSC proteinSCHAD protein |
Information sourced from Uniprot.org