Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions. |
Protein Name | Glutathione S-Transferase Mu 4Gst Class-Mu 4Gst-Mu2Gstm4-4Leukotriene C4 Synthase Gstm4 |
Database Links | Reactome: R-HSA-156590Reactome: R-HSA-9026762 |
Cellular Localisation | Cytoplasm |
Alternative Protein Names | Glutathione S-Transferase Mu 4 proteinGst Class-Mu 4 proteinGst-Mu2 proteinGstm4-4 proteinLeukotriene C4 Synthase Gstm4 proteinGSTM4 protein |
Information sourced from Uniprot.org