Human GRK6 protein (Recombinant) (N-His) (STJP004739)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRK6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRK6 |
| Gene ID | 2870 |
| Uniprot ID | GRK6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe186-Phe448 |
Additional Info
| Post Translational Modifications | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| Protein Name | G Protein-Coupled Receptor Kinase 6G Protein-Coupled Receptor Kinase Grk6 |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneLipid-Anchor |
| Alternative Protein Names | G Protein-Coupled Receptor Kinase 6 proteinG Protein-Coupled Receptor Kinase Grk6 proteinGRK6 proteinGPRK6 protein |
Information sourced from Uniprot.org