Human GRK4 protein (Recombinant) (N-His) (STJP004563)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRK4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRK4 |
| Gene ID | 2868 |
| Uniprot ID | GRK4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg188-Phe449 |
Additional Info
| Post Translational Modifications | Palmitoylated. |
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin.the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. |
| Protein Name | G Protein-Coupled Receptor Kinase 4G Protein-Coupled Receptor Kinase Grk4Iti1 |
| Database Links | Reactome: R-HSA-2514859 P32298-1 |
| Cellular Localisation | CytoplasmCell CortexBoth At The Cell Surface And Dispersed In The Cytoplasm Under Basal ConditionsReceptor Stimulation Results In The Internalization Of Grk4 To The Perinuclear AreaWhere Colocalization With Drd3 Is Observed Strongly At 5 And 15 MinutesDrd3 And Grk4 Colocalize In Lipid Rafts Of Renal Proximal Tubule Cells |
| Alternative Protein Names | G Protein-Coupled Receptor Kinase 4 proteinG Protein-Coupled Receptor Kinase Grk4 proteinIti1 proteinGRK4 proteinGPRK2L proteinGPRK4 protein |
Information sourced from Uniprot.org