Human GRK2 protein (Recombinant) (N-GST) (STJP004413)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRK2-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRK2 |
| Gene ID | 156 |
| Uniprot ID | ARBK1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp398-Leu640 |
Additional Info
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. |
| Protein Name | Beta-Adrenergic Receptor Kinase 1Beta-Ark-1G-Protein Coupled Receptor Kinase 2 |
| Database Links | Reactome: R-HSA-111933Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-5635838Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmCell MembranePostsynapsePresynapse |
| Alternative Protein Names | Beta-Adrenergic Receptor Kinase 1 proteinBeta-Ark-1 proteinG-Protein Coupled Receptor Kinase 2 proteinGRK2 proteinADRBK1 proteinBARK proteinBARK1 protein |
Information sourced from Uniprot.org