Human GRIN2B protein (Recombinant) (N-His) (STJP005302)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRIN2B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRIN2B |
| Gene ID | 2904 |
| Uniprot ID | NMDE2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Tyr1133-Val1484 |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity. |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2bGlun2bGlutamate Nmda Receptor Subunit Epsilon-2N-Methyl D-Aspartate Receptor Subtype 2bNmdar2bNr2bN-Methyl-D-Aspartate Receptor Subunit 3Nr3Hnr3 |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9022699Reactome: R-HSA-9032500Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteLate EndosomeLysosomeCytoplasmCytoskeletonCo-Localizes With The Motor Protein Kif17 Along Microtubules |
| Alternative Protein Names | Glutamate Receptor Ionotropic - Nmda 2b proteinGlun2b proteinGlutamate Nmda Receptor Subunit Epsilon-2 proteinN-Methyl D-Aspartate Receptor Subtype 2b proteinNmdar2b proteinNr2b proteinN-Methyl-D-Aspartate Receptor Subunit 3 proteinNr3 proteinHnr3 proteinGRIN2B proteinNMDAR2B protein |
Information sourced from Uniprot.org