Human GRIN1/NMDAR1 protein (Recombinant) (C-Fc) (STJP008593)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRIN1/NMDAR1-C-Fc protein was developed from mammalian cells for the region C-Fc. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRIN1 |
| Gene ID | 2902 |
| Uniprot ID | NMDZ1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp23-Gln393 |
Additional Info
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 1Glun1Glutamate Nmda Receptor Subunit Zeta-1N-Methyl-D-Aspartate Receptor Subunit Nr1Nmd-R1Hnr1 |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneSynaptic Cell MembraneSynaptic Cell Membrane Targeting Is Dependent Of Grin2b/Glun2b SubunitAssociation With Grin3a Occurs In The Endoplasmic Reticulum |
| Alternative Protein Names | Glutamate Receptor Ionotropic - Nmda 1 proteinGlun1 proteinGlutamate Nmda Receptor Subunit Zeta-1 proteinN-Methyl-D-Aspartate Receptor Subunit Nr1 proteinNmd-R1 proteinHnr1 proteinGRIN1 proteinNMDAR1 protein |
Information sourced from Uniprot.org