Human GRB7 protein (Recombinant) (N-His) (STJP005398)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GRB7-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GRB7 |
| Gene ID | 2886 |
| Uniprot ID | GRB7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser66-Thr327 |
Additional Info
| Function | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. |
| Protein Name | Growth Factor Receptor-Bound Protein 7B47Epidermal Growth Factor Receptor Grb-7Grb7 Adapter Protein |
| Database Links | Reactome: R-HSA-1306955Reactome: R-HSA-1433557Reactome: R-HSA-186763Reactome: R-HSA-210993Reactome: R-HSA-8853659Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic GranuleCell ProjectionPredominantly CytoplasmicDetected In Stress GranulesWhere Mrna Is Stored Under Stress Conditions |
| Alternative Protein Names | Growth Factor Receptor-Bound Protein 7 proteinB47 proteinEpidermal Growth Factor Receptor Grb-7 proteinGrb7 Adapter Protein proteinGRB7 protein |
Information sourced from Uniprot.org