Human GPS1 protein (Recombinant) (N-His) (STJP015232)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GPS1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | GPS1 |
| Gene ID | 2873 |
| Uniprot ID | CSN1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser285-Arg427 |
Additional Info
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
| Protein Name | Cop9 Signalosome Complex Subunit 1Sgn1Signalosome Subunit 1G Protein Pathway Suppressor 1Gps-1Jab1-Containing Signalosome Subunit 1Protein Mfh |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Cop9 Signalosome Complex Subunit 1 proteinSgn1 proteinSignalosome Subunit 1 proteinG Protein Pathway Suppressor 1 proteinGps-1 proteinJab1-Containing Signalosome Subunit 1 proteinProtein Mfh proteinGPS1 proteinCOPS1 proteinCSN1 protein |
Information sourced from Uniprot.org