Human GP2 protein (Recombinant) (N-His) (STJP004961)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GP2 |
| Gene ID | 2813 |
| Uniprot ID | GP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe307-Asn512 |
Additional Info
| Post Translational Modifications | N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH. |
| Function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response. |
| Protein Name | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2Pancreatic Zymogen Granule Membrane Protein Gp-2Zap75 |
| Database Links | Reactome: R-HSA-163125Reactome: R-HSA-9925561 |
| Cellular Localisation | Zymogen Granule MembraneLipid-AnchorGpi-AnchorSecretedCell MembraneApical Cell MembraneMembrane RaftEndosomeAfter CleavageIn The Pancreatic Juice |
| Alternative Protein Names | Pancreatic Secretory Granule Membrane Major Glycoprotein Gp2 proteinPancreatic Zymogen Granule Membrane Protein Gp-2 proteinZap75 proteinGP2 protein |
Information sourced from Uniprot.org