Human GNAL protein (Recombinant) (N-His) (STJP015734)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GNAL-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | GNAL |
| Gene ID | 2774 |
| Uniprot ID | GNAL_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala41-Leu381 |
Additional Info
| Function | Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation. Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP. |
| Protein Name | Guanine Nucleotide-Binding Protein G(Olf Subunit AlphaAdenylate Cyclase-Stimulating G Alpha Protein - Olfactory Type |
| Database Links | Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381753 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Protein Names | Guanine Nucleotide-Binding Protein G(Olf Subunit Alpha proteinAdenylate Cyclase-Stimulating G Alpha Protein - Olfactory Type proteinGNAL protein |
Information sourced from Uniprot.org