Human GM3 Synthase/ST3GAL5 protein (Recombinant) (His-Tag) (STJP018518)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GM3 Synthase/ST3GAL5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ST3GAL5 |
| Gene ID | 8869 |
| Uniprot ID | SIAT9_HUMAN |
| Accession Number | NP_003887 |
| Immunogen | Human |
| Immunogen Region | 83-418aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. mRNA widely distributed in human brain, but slightly elevated expression was observed in the cerebral cortex, temporal lobe, and putamen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer). |
| Protein Name | Lactosylceramide Alpha-2 -3-SialyltransferaseCmp-Neuac -Lactosylceramide Alpha-2 -3-SialyltransferaseGm3 SynthaseGanglioside Gm3 SynthaseSt3gal VSt3galvSialyltransferase 9 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Lactosylceramide Alpha-2 -3-Sialyltransferase proteinCmp-Neuac -Lactosylceramide Alpha-2 -3-Sialyltransferase proteinGm3 Synthase proteinGanglioside Gm3 Synthase proteinSt3gal V proteinSt3galv proteinSialyltransferase 9 proteinST3GAL5 proteinSIAT9 proteinUNQ2510 proteinPRO5998 protein |
Information sourced from Uniprot.org