Human GM2A protein (Recombinant) (N-His) (STJP015701)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GM2A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | GM2A |
| Gene ID | 2760 |
| Uniprot ID | SAP3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | His24-Ile193 |
Additional Info
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity. |
| Protein Name | Ganglioside Gm2 ActivatorCerebroside Sulfate Activator ProteinGm2-ApSphingolipid Activator Protein 3Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative Protein Names | Ganglioside Gm2 Activator proteinCerebroside Sulfate Activator Protein proteinGm2-Ap proteinSphingolipid Activator Protein 3 proteinSap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short proteinGM2A protein |
Information sourced from Uniprot.org